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KMID : 0370220170610050248
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Yakhak Hoeji
2017 Volume.61 No. 5 p.248 ~ p.253
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Effects of Reactive Oxygen Species Induced by Arachidonic Acid on the Stimulation of Melanin Synthesis in B16 Melanoma Cells
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Lee Yong-Soo
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Abstract
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Arachidonic acid (AA) increased production of reactive oxygen species (ROS) in B16 melanoma cells. The AA-induced ROS production and melanogenesis were significantly blocked by treatment with DPI and DIOA, specific inhibitors of NADPH oxidase and K+-Cl--cotransport (KCC), respectively. These results suggest that ROS production by the KCC-linked activation of the NADPH oxidase may play a role in the AA-induced melanogenesis.
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KEYWORD
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arachidonic acid, melanogenesis, reactive oxygen species, NADPH oxidase, K+-Cl--cotransport, B16 melanoma cell
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